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The increased organoid size and decreased apoptosis suggest clonal expansion of stress-resistant cells, implying that epithelial adaptation to chronic oxidative stress may contribute to early remodeling processes within the lung

Crucially, our analysis of scRNA seq data indicated that ROR2 is primarily expressed by mural cells and fibroblasts, suggesting that ROR2 may serve as a pericyte/fibroblast-specific associating kinase of PlexinB1

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Testosterone production tends to peak during adolescence and early adulthood and gradually declines with age